A Cosmological constant problem has been considered in the light of the Standard model ofelementary particles (SM) by account two fundamental fermions in the SM, i.e. the u quark and the electron and their antiparticles. All the movings of these virtual pairs and their orientations in space have been taken into account in the offered model of vacuum. This led to the more precise and accurate estimation of vacuum energy of the Universe on the discovered and examined minimal scale ~1.5×10^-15 m on uncertainty relations, than in the previous work. Comparison of this estimation with the calculation realized by the method and the model used in the previous work was carried out. The current calculation is the full computation, i.e. for the full scale range, which begins from 1.5×10^-15 m and can think terminated for the effect on the maximal linear size2.00008×10^-11 m for the experimental data and the theoretical data on hydrogen and heliumatoms correspondingly. These atoms are considered due to that they are the most common in the entire Universe. Thus, one can say that the vacuum energy near matter in the special effect of the reducing of vacuum by matter has been assessed more precisely as it is in the real world.