A problem of the connection of cosmology with elementary particle physics is shown on thelevel of uncertainty relations. At the scales about 10^-2 m the contribution of one single typevirtual elementary particles in the lower boundary of vacuum energy is considered. The observedvalue of vacuum energy or energy density on the large scale of the Universe corresponds only tothis scale. This is the energy about 3.34 GeV per each one cubic meter. The minimal high energyphysics scale achieved by experiments at present is considered. The lower boundary of theenergy is generated by the quantum vacuum of empty space and the quantum vacuum limited bymatter in the Universe mainly at scales down to 10^-15 m and more much are not in agreementwith the observed value, as that is established. These lower limits for the energies of the vacuumare considered in the model of estimating where they generate by the presence of virtual particlesin free space and the virtual particles which are limited by matter and exist together with matterin the Universe. The numerical values of the boundary energies are obtained using the computeralgorithm.