Biochemistry

   

Speculation on DNA Origami Windmill Model Based on Franklin Figure 51

Authors: Zuodong Sun

Franklin's Photo 51, revealing the periodic diffraction characteristics of DNA, provided key structural evidence for the traditional double helix model. However, the "periodic intensity variation", "symmetrical distribution law" contained in it, and the contradiction between the static map and dynamic physiological functions have not been fully interpreted. Based on this map, this paper proposes an original conjecture of the DNA "origami windmill" model, derived only from the diffraction characteristics of Franklin's Photo 51 and existing literature without supporting experimental data: DNA tetramer forms an inverted conical channel (i.e., inverted trapezoid) surrounded by four fan-shaped leaves, with the outer size larger than the inner size and a central through-hole, which is completely homologous to the inverted conical structural characteristics of potassium channels; the axis core of the DNA windmill is presumably anchored on the fibrous protein scaffold of the nuclear matrix (non-suspended state), consistent with the anchoring logic of the potassium channel windmill protein; cations (potassium ions, sodium ions, calcium ions, etc.) may drive the fan leaves to rotate through thrust when passing through the central hole along the concentration gradient, realizing dynamic movement without the participation of enzymes, which is consistent with the dynamic mechanism of potassium channels; two sets of connected double strands exhibit radial symmetry (extending along the radius direction of the axis core) and are mutually mirror-symmetrical (forming a mirror structure after folding around the axis core), and the dual symmetry characteristics are accurately matched with the cross and signal symmetry laws of the map; during replication, the two sets of connected double strands may separate naturally, and each uses the complete strand as a template to complementarily synthesize new strands, which not only conforms to the core mechanism of semi-conservative replication but also simplifies the process and ensures the integrity of genetic information. This conjecture aims to throw out a brick to attract jade through the dynamic interpretation of the static map, break through the limitations of the traditional double helix model, and provide a new research perspective for explaining DNA dynamic behavior and intranuclear material transport mechanism.

Comments: 7 Pages.

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[v1] 2025-11-24 22:43:39

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