This paper introduces the Energy Hole Model (EHM), as a framework that interprets gravitational interaction as the manifestation of the persistent energy deficit, termed as "energy hole", formed concurrently with the synthesis of mass. It is based on a core hypothesis which states that the synthesis of a mass $M$ requires the confinement of energy $E = Mc^2$, extracted from the surrounding spacetime. This process leaves a corresponding energy deficit (hole) of $-Mc^2$, which acts as the source of the gravitational field. From this premise, we derive the energy hole density profile for point masses, generalize that for stabilized extended objects, and propose a modified Poisson equation. It is demonstrated that a modified Poisson equation recovers Newtonian gravity as a limiting case, and the classical tests, including light bending, Shapiro delay, and gravitational redshift, are in full agreement with observations, establishing their empirical consistency. Beyond reproducing the established tests of general relativity, the EHM provides conceptual resolutions to cosmological puzzles like:(i) the cosmological constant problem, via the corollary of the core EHM hypothesis, which states that energy confinement is a unique physical process, which is not observed in any other phenomenon except mass formation.(ii) the dark matter as the additional energy deficit over that of baryonic mass, (iii) the dark energy as the residual, positive energy of the spacetime vacuum,(iv) and the gravitational behaviour of compact objects and black holes, including the black hole singularity and the hard horizon problem. The gravitation by negative energy is shown explicitly in the Friedmann equations. The EHM thus offers a unified and physically intuitive description of gravity and cosmic structure, fundamentally linking the concepts of energy synthesis, binding, and deficit formation.