This paper introduces a novel unification framework, positing space-time as a superfluid-like medium governed by a universal Space-Time Constitutive Constant (( C_y )), which integrates quantum, nuclear, and cosmological phenomena. Protons at radii ( r > 0.84 , text{fm} ) induce a density field, driving emergent particle interactions through a quantized space-time structure. The model unifies fundamental forces via a single energy-displacement relation, reproducing key experimental results: neutron decay energy (~0.782 MeV), deuterium binding (~2.22 MeV), electron charge (( 1.602 times 10^{-19} , text{C} )), and quantum effects like double-slit interference and the Casimir effect (~10u207b²u2070 J). It addresses Standard Model anomalies, including LHCb’s ( R_K ) (3.1σ), ATLAS’s top quark entanglement (6.7σ), and Fermi-LAT’s electron excess (3.7σ), with a 95—97% likelihood of explanatory success. The framework incorporates relativistic effects, predicting time dilation impacts on particle lifetimes and gravitational analogs in cosmological settings. By modeling space-time as a dynamic, superfluid-like medium, it bridges quantum chromodynamics (QCD) with general relativity, capturing quark-gluon dynamics and gravitational wave signatures. Experimental tests are proposed to validate the model: X-ray free-electron laser (XFEL) experiments to detect orbital energy shifts (0.01—0.1 eV), National Ignition Facility (NIF) measurements of magnetic susceptibility variations (5—10%), Relativistic Heavy Ion Collider (RHIC) probes of strong force shifts (0.1—1 MeV), and Gamma-ray Spectrometer at LIGO (GSL) for weak force decay rate deviations. Space missions are suggested to test flyby anomaly velocity shifts, potentially confirming space-time density fluctuations. Cosmological implications include explanations for cosmic expansion and dark energy via constitutive interactions. The model’s predictive power extends to Event Horizon Telescope (EHT) observations of M87* and Sgr A*, anticipating shadow asymmetries and photon ring distortions. A unified Lagrangian integrates scalar fields and stochastic fluctuations, offering a holographic perspective on particle and gravitational interactions. With falsifiable predictions, the framework invites rigorous testing at facilities like CERN, NIST, and the Paul Scherrer Institute (PSI), potentially revolutionizing our understanding of the universe by linking atomic-scale phenomena to cosmological structures through a single constitutive constant.