Modern physical theories excel at describing the evolution of physical systems through well-defined mathematical laws. However, these laws fundamentally presuppose initial conditions and a structure of observables that they do not themselves explain. In this paper, we argue that current science—while successful in predicting and manipulating nature—is inherently incapable of addressing the question of origins: the origin of the cosmos, life, or even fundamental quantities like mass, charge, and spin. Measurement in science is intrinsically comparative, not absolute, further highlighting a deep epistemological limitation. We critically analyze this structural limitation of scientific methodology and argue that without recognizing these boundaries, attempts to resolve origin-related mysteries remain philosophically and methodologically incomplete. We conclude by calling for a broader paradigm that includes metaphysical, phenomenological, or consciousness-based perspectives to complement scientific inquiry.