Nova proposes quantized spacetime fluctuations (QSFs)—a scalar field ϕ constrained to Planck-scale vacuum perturbations—as the sole constituent of the universe, with no external background,unifying General Relativity (GR) and Quantum Mechanics (QM) at all scales without invokingextra dimensions, geometric quantization, or traditional gauge bosons. QSFs are both quantizedand dynamic, inducing GR’s tensor gravity through a scalar-tensor coupling (κ =116πG ) derivedstep-by-step from gravitational vacuum energy, where gravity manifests as an inertial-like spreadaction driven by relative differences in QSF densities. Particle masses and fundamental forces emergefrom knotted QSF structures defined by Seifert surfaces: the strong force as the knotting potentialat the bare minimum matter level with genus g = 3 and knot size rknot = 10−15 m, the weak forceas the temporal action strength of the knots with g = 2 and rknot = 10−18 m, the electromagnetic(EM) force as a vibration-like spread across QSF patterns with g = 1 and rknot = 3.86 × 10−13 m,and gravity as the relative QSF fluctuations’ spread action around matter-like QSFs. Antimatterarises from stretched, non-knotted QSF actions, created equally with matter (nknot = nanti =7.7 × 10−141 m−3) but isolated by their distinct dynamics, yielding a global symmetry (ηglobal = 0)with local matter dominance (ηlocal = 5.5 × 10−10) explained without parameter tuning. Time isderived from QSF actions, ceasing where action halts (e.g., ∂tϕ = 0), a concept grounded in therelational nature of QSF dynamics. The QSF creation rate β(t) = 3H(t) governs cosmic evolution,derived from the Hubble parameter with detailed justification, coupling to observable scales throughknot dynamics unified under an SO(5) symmetry of QSF patterns, eschewing particle mediators infavor of energy spreads. Nova generates dark matter via non-knotted fluctuations (ρDM = 8.8 ×10−28 kg/m3), produces dark energy via expansion dynamics at ρDE = 7.15 × 10−27 kg/m3, anddrives cosmic inflation through an early high β-rate phase (βinf = 1.8 × 1034 s−1, achieving 60 e-folds). It resolves singularities with a dynamic finite-core metric and eliminates the Hierarchy andStrong CP Problems as artifacts of linear thinking, requiring no fine-tuning or additional particles.We rigorously test against Planck CMB (H0 = 67.4 km/s/Mpc), LIGO GW150914, and LHC Higgsdatasets, computing densities and masses with Monte Carlo error estimates, and predict a 510 ±20 GeV scalar from knot genus g ≈ 60, CMB B-modes at ℓ > 3000 with ∆CBBℓ = 0.8±0.2 µK2, andsubatomic force deviations, all derived with exhaustive clarity from QSF principles.