This article is a comprehensive survey describing our search for life and aliens beyond earth. The search for life inside our Solar System continues by digging into the Martian soil and exploring the underground oceans of Jupiter’s moon Europa. As we peer into the Milky Way, exoplanets are the target. Improved sky-survey telescopes identify exoplanets. Then, subsequent analysis using spectrographs obtained via exoplanet transits or direct imaging hope to identify biosignatures. Detection of intelligent life is either circumstantial or definitive. Technosignatures offer circumstantial evidence of alien civilizations. Definitive or positive detection can be physical, for example, discovering interstellar objects (spaceship/UFOs) or as in the movie Contact, an alien message. Future giant optical/infrared telescopes, sophisticated radio telescopes, and a proposed space telescope, HWO, will dramatically enhance detection.Significant technical advances in earth-based and space telescopes, documented in four key figures, dramatically improve the probability of discovery over the next ten years. Thus, we may soon have an answer to the question, are we alone?