This study proposes specific experimental approaches to validate the theory presented in "Self as the Core of Biological Feedback Systems: An Ideogrammatic Model of Memory and Recognition." First, it discusses the premise that information must possess at least a one-dimensional structure in physical form. If a material responsible for memory exists within cells, it is highly likely to be linear proteins (e.g., talin, actin, microtubules) with one-dimensional structures that store information. To test this hypothesis, nanopore and Raman spectroscopy-based analytical techniques are designed. To apply nanopore technology derived from DNA sequencing to protein analysis, the study explores methods for either preserving the three-dimensional structure of proteins or converting them to their one-dimensional form during preprocessing, determining the physical characteristics of nanopores, and analyzing the resulting signals. Particularly, surface-enhanced Raman spectroscopy (SERS) is proposed as a method to analyze structural changes in proteins in real-time and evaluate their potential for information storage. This research presents a novel experimental approach to understand memory and information storage mechanisms at the protein level, providing concrete directions to validate the theoretical hypothesis.