This paper investigates the potential coupling between gravitational fields and quantum vacuum fluctuations, as evidenced by variations in the Casimir effect. The Casimir effect is a quantum phenomenon that arises from electromagnetic vacuum modes between two closely spaced plates, resulting in a force inversely proportional to the fourth power of their separation. This study hypothesizes that gravitational fields, by curving spacetime, may influence these vacuum modes, leading to measurable changes in the Casimir force. Existing precision experiments on the Casimir effect and short-range gravity tests are reviewed for their suitability in probing this hypothesis. Proposed experiments under varying gravitational conditions—Earth’s surface, high-altitude stations, and microgravity environments—are detailed, along with the inclusion of a strong local gravitational source (e.g., a massive tungsten sphere). If verified, such interactions would provide experimental evidence for a direct connection between quantum mechanics and general relativity, with profound implications for physics.