| viXra.org > Physics of Biology > viXra:2411.0018 |
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| viXra.org > Physics of Biology > viXra:2411.0018 |
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Physics of Biology |
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Authors: Hyunho Shin
This study proposes an innovative therapeutic approach for Alzheimer’s disease (AD) targeting the aggregation and clearance of the neurotoxic amyloid-beta 42 (Aβ42) peptide. Utilizing computational design tools such as AlphaFold 2, we identified and optimized functional peptides capable of binding the hydrophobic C-terminal region of Aβ42 to prevent aggregation and promote degradation via the ubiquitin-proteasome system (UPS). This non-invasive strategy envisions peptide administration through a nasal ultrasonic nebulizer, which could bypass the blood-brain barrier (BBB) and deliver peptides directly to the brain. The concept focuses on the potential of combining targeted peptide design with a delivery system that enables rapid, brain-specific absorption, presenting a novel direction for AD therapy.
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[v1] 2024-11-03 22:54:12
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