This paper attempts to use the Seiche phenomenon to explain a huge flood that occurred in the Liangzhu region of Zhejiang Province in the middle and lower reaches of the Yangtze River 4,300 years ago. According to the available archaeological evidence, the height of this flood reached about 100 meters. The cause of this Seiche phenomenon is the dam failure of glacial lakes formed in the Tarim and other basins in the western plateau of China after the end of the last glacial period. This paper estimates that if the dam of the Tarim Basin, which is filled with glacial lake water, fails, the flood water can easily flow into the East China Sea through the Hexi Corridor, causing geological disasters such as earthquakes, leading to a chain of dam failure effects in other basins in the west, and then more massive floods. The potential energy of the floods generated by the dam failure of these glacial lakes is enough to cause Seiche standing waves up to 150 meters high and 5 kilometers in wave length in places such as the East China Sea. Such a high amplitude Seiche standing wave may be the cause of the great flood in the Liangzhu area 4,300 years ago. Considering that the current global climate is rapidly warming and may cause more severe flooding, this paper also estimates that if a 30-kilometer radius of Greenland ice sheet dissolves and dumps into the ocean, the potential energy carried by this ice sheet will propagate to the North Sea in northern Europe, potentially causing Seiche standing waves with amplitudes of up to 50 meters. This Seiche standing wave can last for months, or even years. This will have a very serious impact on the countries bordering the North Sea and require our attention.