Unifying Special Relativity (SR), General Relativity (GR), and Quantum Physics (QP) remains one of the most profound challenges in theoretical physics. While each framework has achieved extraordinary empirical success, they become mutually incompatible under extreme conditions such as the earliest moments of the universe or the interior of black holes. Cosmological observations, including dark matter, dark energy, and the Hubble tension, further expose gaps in our understanding. Existing unification attempts, such as String Theory, Loop Quantum Gravity, and Grand Unified Theories, have not yet produced a complete and experimentally verified solution.This paper argues that unification becomes possible once the global physical structure of the universe is properly identified. I propose a framework in which quantum physics occupies a central role in cosmology. Within this view, the quantum vacuum is not an empty void but an infinite medium filled with fluctuating fields and transient virtual particles. Quantum Field Theory (QFT) thus provides a natural foundation for both the origin of matter and the large-scale organization of the cosmos. The novelty of this approach lies in linking the quantum vacuum directly to the universal structure, offering a pathway toward reconciling relativistic and quantum descriptions within a single framework.