The purpose of this article is to outline a framework of concepts and principles to combine quantum mechanics and general relativity so that time and measurement (reduction) are present as integral parts of the basic foundations. First, the problem of time in quantum gravity and the measurement problem in quantum mechanics are briefly reviewed and the popular proposals to tackle these two problems are briefly discussed. Next, on the already known foundations of quantum mechanics, a framework of principles of dynamics is built: 1) Self-Time Evolution - Newtons first law is reinterpreted to define time, 2) Local Measurement by Local Reduction - Quantum diffusion theory is adapted, and 3) Global Evolution by Global Reduction. Ideas on how to apply the framework to study quantum general relativistic physics are discussed. Further, more general and modified forms of some of these principles are also discussed. The theoretical elements in the framework to be made concrete by further theoretical and experimental investigations are listed. Revision information is included.