The Silies has been investigated as a possible al-- the DNA double helix - sometimes doubles up again. Researchers have now found this quadruple-stranded form in healthy human cells for the first time. Speculate that the quadruplex structure forms to hold the molecule open and facilitate the reading of the genetic code and thus the production of proteins. G-quadruplex DNA is a four-stranded structure made that can form a ’knot’ in the DNA of living cells. In these terms, it was analyzed through computationalcalculations, via MM(Molecular Mechanics), and byab initio Restricted Hartree-Fock (RHF) method, on a simple STO-3G (Slater-type orbitals with 3 Gaussians) basis, the possibility of a DNA macromolecule based on Silicon. From the basic structure of 1bna, however, you assume conditions without the presence of Carbon, replacing it with Silicon. It was obtained a cluster of G-quadruplex DNA, forming a cocoon, with great possibility for the pharmaceutical industry in capturingmolecules foreign to human DNA.