The Doppler shift could be applied to directional neuronal connectivity involving change in frequency ν±Δν of wave that is moving relative to the wave source, acting over neuronal circuit distancing. The 1s orbital of the hydrogen atom allows the electron spin-flip up and down to emit radio emission at 18cm from hydroxyl radical and 21cm atomic hydrogen, which combined form water. This strongest spectral line of the hydrogen, present in the Dark Ages and by radio astronomy detected from primordial galaxies, is emitted by the water of all tissues, medically applied for brain studies, by magnetic resonance imaging (MRI). Hence, a Doppler Effect imaging of the distancing dynamics allows neuronal connectivity by their emission spectrum frequencies. Hence, the assay of nano scales coherence or distancing thermodynamics, equivalent to the plasticity strength of neuronal movement for electric connectivity. Therefore its interpreting measure an equivalent of crosstalk between neurons and its elucidation became an analog to a translation of this unknown process. The transmembrane enzymes generate the enthalpy, coupled to the metabolism of glucose and water cluster. The products CO2 and water as vapor are exhaled at the mouth as entropy. This integrative model allows a joint perspective of multiple layers of the reality, conditioned by scale dimension. Thus, the metrics of the quantum mechanics realm could show the locals frames for superposition of space and simultaneity. The brain thermodynamics relationship between inputs of glucose and the enthalpy process of metabolic energy (heat), coupled homeostatically at 36.6℃ to water cluster H-bond breakdown, which in the cerebrospinal fluid (CSF) flow in microtubules could circulate in a liquid state as dimers (H2O~OH2) to dissipate entropy as vapor in the oral cavity. The multi-layers at neuron scale manifest spin in antenna role to signal connectivity for axon, dendrites, microtubules and tunneling. Myelinated space is a thermodynamic closed system, which eventually tends to equilibrium between enthalpy and entropy in which free energy cannot produce work. At a myelinated axon the Nodes of Ranvier "jumps" from node to node operate the unmyelinated stretches as a nano open space-time system. Quantic thermodynamic allows a repetitive sequence at the nano level of close to open, close to open, close u2026 Hence, a maximal value of enthalpy is conserved and entropy became dissipated outside the system, maintaining the action potential level in steady state. (Truncated by viXra Admin to < 400 words)