Wetlands are very important because of the wide range of ecosystem services they provide. Despite their ecological, social and environmental importance, these ecosystems are threatened and fragmented under the combined effects of climate change (CC) and man-made activities (MMA). Such a state of things could be exacerbated by the advent of the coronavirus disease 2019 (COVID-19) pandemic with its many implications. In order to help decision-makers take good decisions, the combined effect of CC, MMA and COVID-19 on the livelihoods of communities around wetland ecosystems have been reviewed based on available scientific knowledge. First, we analyzed the different concepts and theories underlying the wetlands-related studies and then summarized the merits and demerits of the different methodologies underlying wetland studies. The empirical evidences that exist in previous literatures have been highlighted. Similarly, common livelihood strategies for wetland communities in Sub-Saharan Africa (SSA) have been highlighted. The review helped to identify that, out of the three factors investigated, the livelihoods of rural wetland dwellers in SSA are mostly influenced by CC and MMA. However, climate change and COVID-19 remain life-altering transboundary threats that extend in space and time, with large uncertainties on wetlands communities livelihoods.