A liquid water state transition to vapor at the physiological parameter is hereby described by adenylate cyclase (AC) function in neuronal membranes, across hydrophilic and hydrophobic regions. The cerebral enzymatic reactions involves Mg exceeding ATP as a substrate reacting with polymeric liquid H2O (n=3.4) to produce Pyrophosphate (Pi) and AMP. The closing of the ring to form cAMP and release H2O. The individual molecules by forming entangled pairs, which could not fit into the active site, avoid reentering in a backward reaction. Thus, but still have turnover to free the enzyme from the product to interact with substrate polymeric liquid water, complete its cycle and eludes microscopic reversibility. The latter, vapor state is present at 5% concentration in exhaled air. This physiological state transition allows that the critical point for change of state, for 500ml water within the cerebrospinal fluid (CSF) occurs at 36.6 oC. The entangled pairs as a whole adopt an entanglement state. Obviously, the individual molecules could not circulate in the vapor state within the astrocytes system. However, paired do at a rate of 1.6E16 pairs per milliseconds (ms), greater that AC operational turnover. The water paired structure could oscillate between two states, one entangled by two oxygen atoms in the pair, and the other, by two structures of two entangled hydrogen atoms in the pair. The system allows directionality propagation to the uniformly entangled pairs allows by the hierarchical of the initial effect. At a dissipative forming rate of 1.6E16 pairs per ms allow a liquid state to water within the astrocytes. Individual molecules were operated by entanglement to allow a physiological function of cooling the body by releasing heat as vapor, at body temperature. Energy-Consuming Processes in the Brain by vasoactive intestinal peptide (VIP), adrenaline in tissues AC, and noradrenaline (NA) activated AC in brain. The glycogenolysis actions and the adenylate-cyclase cascade, coupled to the release of vapor out of the system. These create an open system preventing any metabolic reversibility even by a short time to the functional brain.