Yagya has been one of the core elements of the ancient Indian Culture ever since the Vedic era, and is also an effective therapeutic procedure. The present review article explores the applicability of Yagya during the present time, wherein the principles, procedure and the possible mode of action of Yagya have been described; the efficacy of Ayurvedic medicines and medicinal herbs in the management of various diseases caused by viruses, as well as the diseases that have symptoms similar to those prevalent during present time, have been discussed; the ethnobotanical use of herbal fumigation in the management of various diseases, has been presented; as well as, the efficacy of Yagya Therapy / Integrative approach (including Yagya Therapy) in the management of symptoms of various disease conditions has been illustrated. The review also briefly illustrates the ancient Ayurvedic perspective about epidemics and the possible role of Yagya as a management approach for the same. Based on the information presented herein, the applicability of Yagya in the present time seems to be a promising possibility, that is worth exploring further through proper experimentation and analysis.