Quantitative Biology

    

Kidney Filtration Pressure as a “single Effect” for Osmotic Gradient

Authors: Johan Nygren

Consider the name of the renal pyramids, and that it points to them being pyramidal. This anatomy suggests the “urine compartment”, the nephrons and collecting ducts, narrows from the base of the renal pyramid (cortex) to the top (papilla), in the same way as a funnel. This anatomical arrangement likely has a role in the reabsorption of 99% of all filtrate produced per day, simply by providing resistance. If this architecture is able to contribute to reabsorption of water, and, by that, concentration of urine, and if this concentrated urine to some extent equilibrates with the surrounding medullary interstitium, then it would provide a “single effect” for an osmotic multiplier.

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[v1] 2020-05-20 15:25:51

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