A model of human brain evolution should take in account the constitutive separation of two integrated parameters: the one for neuronal synapsis and circuits, from that by a multiple wrapped-around astrocytes and their exchanges. The main function of glial cells is the absorption of the generated, thermal-like breaking of H-bonds, from polymerized water provides the activation energy, coupled for the turnover of structural changes, between hydrophobic and hydrophilic enzyme forms. Thus, increasing rotational and vibrational kinetic activity, on the separated individual H2O molecules, but maintaining a liquid coherence, during circulation within astrocytes until the lower pressure at the vomeronasal organ (VNO) allows phase conversion to vapor, equivalent to entropy dissipation. The summation of the energy generated by metabolites and H-bond consumption allows the brain thermodynamics to support ratios between metabolite concentrations and the electrogenic action potential in dissipative states, within an open system. Cell-free DNA (cfDNA) from an evolutive disaggregation of the olfactory bulb, are still present as an olfactory epithelium, adapted for sex pheromones and behavioral responses stimulus on adenylate cyclase (AC) for cAMP-dependent unzipping of the DNA. It is a focused process to create neurons differentiated by where the cAMP is inserted, which creates specific neural circuits. Olfactory epithelium may hold the neurons with 7TM receptors for the saliva or pheromones, reaching the oral cavity with their axons crossing the BBB. This allows cffDNA response through cAMP complexing and messenger RNA expression into polypeptide holding a transitory memory during baby rearing, as a psychosomatic molecular carrier of emotional and communication needs of a newborn, which functions to form an unconscious level, which diversifies individual emotional characteristics, approaching a level of animic personalities, which when age allows a conscious level, could offer differentiable roles for social influences that allow the brain self-plasticity such as literacy.