Dewetting transition is transient phenomenon taking place inside the hydrophobic pores of ion channels that forbids water molecules to cross microscopic receptor cavities and leads to impairment of cellular performance. It has been recently suggested that artificially-provoked dewetting transition in ion channel hydrophobic pores might stand for a molecular candidate to erase viruses, bacteria and cancer cells, and to block autoimmune activities. A novel type of high-affinity monoclonal antibody has been suggested, that is equipped with lipophilic and/or hydrophobic fragments that prevent physiological water flow inside ion channels and targets specific trans-membrane receptor structures of influenza viruses. Here we suggest that these dewetting monoclonal antibodies targeting the 2019-nCoV viroporin channels, sprayed in the nasal cavities, might lead to virion impairment, thus preventing inter-human viral transmission.