 |
 |
Chemistry |
|
Authors: Giri Prasad Gorumutchu1, Venkata Nadh Ratnakaram2, Kishore VNV3
A simple visible spectrophotometric method is proposed for the determination of ulipristal acetate present in bulk and tablet formulation. The currently proposed method is established based on MBTH oxidation by ferric ions to form an active coupling species (electrophile), followed by its coupling with the ulipristal in acidic medium to form high intensi��ied green colored chromophore having max at 609 nm. Validated the method as per the current guidelines of ICH. Beer’s law was obeyed in the concentration range of 6.25 – 37.50 g mL��1 with a high regression coef��icient (r > 0.999). Reproducibility, accuracy, and precision of the method are evident from the low values of R.S.D. This method can be used in quality control laboratories for routine analysis of ulipristal acetate in bulk drug and pharmaceutical dosage forms.
Comments: 7 Pages.
Download: PDF
[v1] 2019-11-01 07:10:41
Unique-IP document downloads: 391 times
Vixra.org is a pre-print repository rather than a journal. Articles hosted may not yet have been verified by peer-review and should be treated as preliminary. In particular, anything that appears to include financial or legal advice or proposed medical treatments should be treated with due caution. Vixra.org will not be responsible for any consequences of actions that result from any form of use of any documents on this website.
Add your own feedback and questions here:
You are equally welcome to be positive or negative about any paper but please be polite. If you are being critical you must mention at least one specific error, otherwise your comment will be deleted as unhelpful.
| Third-Party Links: |
|