Hypersonic cruise vehicles are fly at Mach numbers of above five (7) and the aerodynamic heating would be severe. Hypersonic Vehicles encounter a severe hazardous environment such as extremely high temperature plane to aerodynamic heating, fluctuating pressures, stresses for which the structures are to be designed and fabricated to withstand these environments to protect various electronic items like guidance, control and instrumentation systems housed in the vehicle structure. High temperature of the order of 15000C and above during the hypersonic flight causes enormous thermal stresses. Inconel-617 is a Nickel based alloy. Hence Inconel-617 is employed as a sandwich material. Theoretical & ANSYS modeling analysis have been done for both, the square and hexagonal honeycomb panels of Inconel-617 material have been performed to suit the hypersonic flight conditions. The honeycomb structures are built from thin walled metal sheets. These structures as a part of the airframe outer cover provide thermal protection to the interior parts mounted inside the vehicle. This paper is to perform geometrical (shape) analysis of different candidate honeycomb cells that have the same effective density but different geometrical shapes. To perform heat-transfer analysis of hypersonic aerospace vehicle structure with different honeycomb cell geometry.