While the reductionist approach, best expressed in Descartes’ Method, helped science to develop along the objectivity principle, the modern crisis in quantum mechanics and cosmology calls for a return to a traditional holistic viewpoint, where the large would explain the small. This could lead to replacing the concept of ‘emergence’ (where the whole exceeds the parts) by that of ‘immergence’ (foreseen in Mach’s conjecture). This implies a temporal invariance of the cosmological parameters defined by applying the Bekenstein-Hawking holographic principle. This latter is associated with a coherence principle according to which any well-defined system (such as a living organism) is associated with a specific frequency, analogous to the clock of a computer. Physical laws would then be related to a computing process. This coherence principle is shown to be central in atomic physics and defines Coherent Cosmology, which can be seen as a synthesis of standard cosmology and steady-state cosmology, completed by a ‘Grandcosmos’ extending the observable Universe radius by a factor 1061 and associated with the Cosmic Microwave Background (CMB). For the observable Universe, there is a specific frequency of 10^104 Hz, introducing a quantization of space-time 10^61 smaller than Planck’s scale. The Universe equivalent mass is expressed in terms of the main three microphysical masses: electron, proton, and hydrogen; all microphysical masses would be submultiples of it. The dimensionless ‘large numbers’ issued from Cosmology and Microphysics are shown to enter a Topological Axis with an emphasis for 26 dimensions, rehabilitating the Bosonic String Theory and pointing to massive gluons and superspeed signals. The Kotov non-Doppler coherent cosmic oscillation appears as an absolute clock, in holographic connection with the background. Generalized holographic conservation yields the critical condition while the trivial matter density 3/10 solves the dark energy problem. A systematic elimination of c helps to relate the physical parameters to Kotov’s well-measured cosmic period: 9600.61(2) s, and c-free standard dimensional analysis confirms the invariance of the Universe horizon, matter density, and background temperature. The later appears related to the triple-point temperatures of H2, O2, and H2O, and to mammals’ temperature through Sternheimer’s scale factor: j = 8 pi^2/ln2, which itself is related to the electric constant: a ≈ 137.036. Analysis of the masses of DNA nucleotides and protein amino-acids shows a connection with Kotov’s period, suggesting that DNA could be a linear hologram. The Darwinian step-by-step macroevolution theory, by unrelated random mutations and natural and sexual selection, seems then irrelevant. We have also investigated the relations between physical canonical large numbers and economic and musical numbers, hinting that the human brain may act as a multi-basis computer, favoring the universality of Intelligent Life.