Three advances are proposed as a pathway to the cataclysmic event of our first encounter with intelligent extraterrestrial Beings. First, discovery of very large numbers of extraterrestrial planets, “Exoplanets” (approximately 1023 in our Universe); second, introduction of electronic components into the human body evolving into a cybernetic and biological “cyborg,” a model for an extraterrestrial Being. Cyborgs might allow advanced civilizations to endure hundreds of thousands of years and third, the recent development of high-frequency gravitational wave (HFGW) detectors; the communication means of choice for an advanced, cyborg civilization since they are not easily absorbed like electromagnetic radiation. Six HFGW detectors are presented for application to our first encounter with intelligent extraterrestrial Beings. Numerical estimates are made for the failure of extraterrestrial civilizations such that no two exist at the same time (Fermi’s Paradox). It is concluded that there might remain at least ≈ 1.48x10^8 Worlds intercommunicating with HFGWs at any one time in any one region of our Universe. We predict the form of such Beings by an imaginary projection of the evolution of “Earthling” homo sapiens to become “cyborgs.” We propose that such cyborg forms of intelligent Beings would be encountered by us. The first cataclysmic encounter with them is expected to be interception of their interstellar communications. The predicted frequency of intercepted messages under one set of assumptions is at least 1,500 per day. After decoding the intercepted messages, keys may be found to improve vastly the present and future quality of life for us earthlings. Advanced Beings might utilize direct brain-to-brain communication and it is concluded that research into brain-to-brain communication and HFGW detection be encouraged.