Neutrosophy is a new branch of philosophy that studies the origin, nature, and scope of neutralities, as well as their interactions with different ideational spectra. There are many similarities between The Golden Mean and Neutrosophy. In order to achieve the mission of the expansion and development of The Golden Mean towards "modernization" and "globalization", not only Chinese scholars, but also foreign scholars should participate in this mission, and not only Chinese contemporary popular ideas and methods, but also foreign contemporary popular ideas and methods should be applied. There are many different ways for interpretating and expanding The Golden Mean with “Neutrosophic tetrad”(thesis-antithesis-neutrothesis-neutrosynthesis), and come to different conclusions. This paper emphasizes the one conclusion that in practice, The Golden Mean cannot be applied lonely for long-term; it needs to be combined with other "principle".