Galileo was convinced that the book of the Universe was “written in the language of mathematics, [whose] characters are triangles, circles and other geometrical figures, without which it is humanly impossible to understand a single word of it; without these, one is wandering around in a dark labyrinth” [1]. Similarly, Albert Einstein, at a conference at Kyoto University in 1922, stated: “The fundamentals of geometry have a physical significance” [2]. These observations, made by the two noble fathers of modern physics, have the potential to subvert the standard perspective of present-day science. The principal of complementarity has, however, been underestimated and has not produced the effects that it might. In contrast, the holistic theory of limits (unknown in the literature) – in ideal continuity with Galileo and Einstein – unifies the quantum fundamentals of geometry with the laws of physics and creates the initial conditions for elaborating a theory of the Whole that can describe physical reality in a unitary context and on all scales of magnitude. In accordance with the premise, the holistic theory of limits enunciates the following theorem: The interaction of a flow of radial energy with the fundamentals of geometry generates a virtual quantum configuration (of ideally spherical symmetry) known otherwise in the literature as quantum void. This configuration is the geometrical locus within which energy is converted into corresponding mass and where the principal physical-numerical magnitudes that confer materiality to the Universe, from quarks to the universal physical constants, are generated. The dynamics of events thus triggered generate the number alpha, fine structure constant, dominus of the universe (said by Nobel laureate Feynman to be “one of the most enigmatic riddles”). Einstein spent the last years of his life in a vain attempt to find a theory capable of unifying the electromagnetic field with the interaction of gravity: the holistic theory provides the trigonometric solution of the phenomenon. Geoffrey Chew, a pupil of Fermi, asserted that the universe was unitary, everything in it being correlated with the Whole. The holistic theory of limits extends that theory from the infinitely great to the microcosm, and this unification makes it possible to reconstruct the shared origin of matter and of the interaction of gravity. The results shown have been obtained by applying the multidisciplinary method of inquiry suggested by Descartes. [1] Galileo Galilei, Il Saggiatore, 1623. chap. VI (published in English under the title The Assayer, translation by Stillman Drake, 1957). [2] ex multis: A. Einstein Come io vedo il mondo Ed. Newton p.45, 92, University of Bologna progettomatematica.dm.unibo.it/NonEuclidea/File/ellittica6.htm