Bronchodilatation response is often used in theassessment and the diagnosis of bronchial asthma. Many clinics and peripheral hospitals have no facility for spirometry and post bronchodilatation response (PBR) assessment. To test the predictors of PBR in asthmatic patients we retrospectively reviewed 100 cases of asthmatic patients followed by our outpatient department. All patients had pulmonary function tests (PFT) on first presentation, 45% M, 55% F, Mean age SD was 38.518 (range: 9-86 years), 92% of the cases were using medication: 89% inhaled beta agonists, 65% inhaled steroids, 7% Ipratropium, 32% oral theophylline, 4% sodium Cromoglycate, and 8% oral prednisone. 82% had shortness of breath, 62% wheezing, 71% cough, 51% nocturnal symptoms, 22% had associated allergic symptoms, and 33% had positive family history for asthma. 48% of the cases had significant PBR (ATS standards). Analysis of the above variables, revealed that a significant association between the bronchodilatation response and the use of medication (Odd Ratio OR=7.2, p ¡ 0.05), nocturnal symptoms (OR = 8:4, p < 0:001) and family history (OR = 2:9, p < 0:05). Conclusion: in asthmatic patients, current use of medications, presence of nocturnal symptoms, and positive family history of asthma , may predict the possibilities of the presence of a significant response post bronchodilatation.